The Monkey Gland Cocktail was created in the 1920s by Harry MacElhone, the owner of Harry's New York Bar in Paris. The drink was named after a surgical procedure of the same name that was popular at the time, and was said to have a restorative effect on the body. The Monkey Gland #2 Cocktail is a variation of the original that uses orange juice in place of the original's Calvados.